Phys. Rev. E 87, 032710 (2013) [5 pages]

Impact of intrinsic biophysical diversity on the activity of spiking neurons

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Man Yi Yim, Ad Aertsen, and Stefan Rotter
Bernstein Center Freiburg & Faculty of Biology, University of Freiburg, Freiburg, Germany

Received 21 August 2012; revised 15 January 2013; published 13 March 2013

We study the effect of intrinsic heterogeneity on the activity of a population of leaky integrate-and-fire neurons. By rescaling the dynamical equation, we derive mathematical relations between multiple neuronal parameters and a fluctuating input noise. To this end, common input to heterogeneous neurons is conceived as an identical noise with neuron-specific mean and variance. As a consequence, the neuronal output rates can differ considerably, and their relative spike timing becomes desynchronized. This theory can quantitatively explain several recent experimental findings.

©2013 American Physical Society

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