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The Journal of Neuroscience, November 24, 2010, 30(47):15760-15768; doi:10.1523/JNEUROSCI.3874-10.2010

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Behavioral/Systems/Cognitive
Gating of Signal Propagation in Spiking Neural Networks by Balanced and Correlated Excitation and Inhibition

Jens Kremkow, Ad Aertsen, and Arvind Kumar

Bernstein Center Freiburg, Neurobiology and Biophysics, Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany

Correspondence should be addressed to Arvind Kumar at the above addresses. Email: arvind.kumar@biologie.uni-freiburg.de

Both ongoing and natural stimulus driven neuronal activity are dominated by transients. Selective gating of these transients is mandatory for proper brain function and may, in fact, form the basis of millisecond-fast decision making and action selection. Here we propose that neuronal networks may exploit timing differences between correlated excitation and inhibition (temporal gating) to control the propagation of spiking activity transients. When combined with excitation–inhibition balance, temporal gating constitutes a powerful mechanism to control the propagation of mixtures of transient and tonic neural activity components.

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Received July 26, 2010; revised Sept. 22, 2010; accepted Sept. 23, 2010.

Correspondence should be addressed to Arvind Kumar at the above addresses. Email: arvind.kumar@biologie.uni-freiburg.de

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