Improvement in hippocampal kindling analysis through computational processing data.
Department
Neurosurgery, Center for Epilepsy, University Medical Center Freiburg,
Albert-ludwigs-University, Freiburg, Germany. joacirgc@hotmail.com
The
kindling phenomenon is classically investigated in epileptology
research. The present study aims to provide further information about
hippocampal kindling through computational processing data. Adult
Wistar rats were implanted with dorsal hippocampal and frontal
neocortical electrodes to perform the experiment. The processing data
was obtained using the Spike2 and Matlab softwares. An inverse
relationship between the number of 'wet dog shakes' and the Racine's
motor stages development was found. Moreover it was observed a
significant increase in the afterdischarge (AD) duration and its
frequency content. The highest frequencies were, however, only reached
at the beginning of behavioral seizures. During the primary AD, fast
transients (ripples) were registered in both hippocampi superimposed to
slower waves. This experiment highlights the usefulness of
computational processing applied to animal models of temporal lobe
epilepsy and supports a relevant role of the high frequency discharges
in temporal epileptogenesis.
PMID: 19722048 [PubMed - in process]