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The high-conductance state of cortical networks.
Kumar A, Schrader S, Aertsen A, Rotter S
Neural Comput 2008 Jan 20(1):1-43 [abstract on PubMed] [citations on Google Scholar] [related articles] [full text] [order article]
Selected by | Alain Destexhe
Evaluated 10 Dec 2007
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Faculty Member Comments
Alain Destexhe
Centre National de la Recherche Scientifique (CNRS), France

New Finding
This article investigates how network of neurons generate "high-conductance" (HC) states of activity similar to in vivo measurements in neocortex. This study is original in using conductance-based synapses, which enable the authors to check the model against conductance measurements in vivo. It is found that self-sustained HC states require large numbers of neurons with very sparse connectivity, but interestingly, current-based models do not seem to display similar activity states without external input.

Competing interests: None declared
Evaluated 10 Dec 2007
Faculty Comments & Author Responses

How to cite the Faculty of 1000 Biology evaluation(s) for this paper

1) To cite all the evaluations for this article:

Faculty of 1000 Biology: evaluations for Kumar A et al Neural Comput 2008 Jan 20 (1) :1-43 http://www.f1000biology.com/article/id/1097198/evaluation

2) To cite an evaluation by a specific Faculty member:

Alain Destexhe: Faculty of 1000 Biology, 10 Dec 2007 http://www.f1000biology.com/article/id/1097198/evaluation

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