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September 2008, Vol. 20, No. 9, Pages 2133-2184
Posted Online July 14, 2008.
(doi:10.1162/neco.2008.05-07-525)
Dependence of Neuronal Correlations on Filter Characteristics and Marginal Spike Train Statistics Tom Tetzlaff* Bernstein
Center for Computational Neuroscience, Albert-Ludwigs-University,
D-79104 Freiburg, Germany, and Institute of Mathematical Sciences and
Technology, Norwegian University of Life Sciences, N-1432 Ås, Norway. tom.tetzlaff@umb.no Stefan Rotter Bernstein
Center for Computational Neuroscience, Albert-Ludwigs-University,
D-79104 Freiburg, Germany, and Theory and Data Analysis, Institute for
Frontier Areas of Psychology and Mental Health, D-79098 Freiburg,
Germany. stefan.rotter@biologie.uni-freiburg.de Eran Stark Department of Physiology, Hebrew University of Jerusalem, Jerusalem 91120, Israel. eranst@ekmd.huji.ac.il Moshe Abeles Gonda Brain Research Institute, Bar Ilan University, Ramat-Gan 52900, Israel. abelesm@mail.biu.asc.il Ad Aertsen Bernstein
Center for Computational Neuroscience, and Neurobiology and Biophysics,
Faculty of Biology, Albert-Ludwigs-University, D-79104 Freiburg,
Germany. aertsen@biologie.uni-freiburg.de Markus Diesmann Bernstein
Center for Computational Neuroscience, Albert-Ludwigs-University,
D-79104 Freiburg, Germany, and Brain Science Institute, RIKEN, Wako
City, Saitama 351-0198, Japan. diesmann@brain.riken.jp *Tom Tetzlaff is presently affiliated with the Norwegian University of Life Sciences.
Correlated
neural activity has been observed at various signal levels (e.g., spike
count, membrane potential, local field potential, EEG, fMRI BOLD). Most
of these signals can be considered as superpositions of spike trains
filtered by components of the neural system (synapses, membranes) and
the measurement process. It is largely unknown how the spike train
correlation structure is altered by this filtering and what the
consequences for the dynamics of the system and for the interpretation
of measured correlations are. In this study, we focus on linearly
filtered spike trains and particularly consider correlations caused by
overlapping presynaptic neuron populations. We demonstrate that
correlation functions and statistical second-order measures like the
variance, the covariance, and the correlation coefficient generally
exhibit a complex dependence on the filter properties and the
statistics of the presynaptic spike trains. We point out that both
contributions can play a significant role in modulating the interaction
strength between neurons or neuron populations. In many applications,
the coherence allows a filter-independent quantification of correlated
activity. In different network models, we discuss the estimation of
network connectivity from the high-frequency coherence of simultaneous
intracellular recordings of pairs of neurons.
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