Faculty of 1000 Biology | Controlling synaptic input patterns in vitro by dynamic photo stimulation.

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Controlling synaptic input patterns in vitro by dynamic photo stimulation.
Boucsein C, Nawrot M, Rotter S, Aertsen A, Heck D
J Neurophysiol 2005 Oct 94(4):2948-58 [abstract on PubMed] [citations on Google Scholar] [related articles] [FREE full text]

Selected by | Alain Destexhe
Evaluated 5 Jul 2005
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Alain Destexhe
Centre National de la Recherche Scientifique (CNRS), France
NEUROSCIENCE

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This article introduces a laser-guided system to recreate in vivo-like activity in cortical slices, by using photosensitive caged glutamate. The main originality of the system is the ability to stimulate quasi-randomly all through the slice, thereby recreating a mean level of activity in the network, which can be related to membrane potential fluctuations in intracellular recordings. With such methods, it becomes possible to finely tune network activity in the slice, and study its impact on the integrative properties of neurons or small circuits.

Competing interests: None declared
Evaluated 5 Jul 2005

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