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Unitary events in multiple single-neuron spiking activity: I. Detection and significance.
Grun S, Diesmann M, Aertsen A.
Department
of Neurophysiology, Max-Planck Institute for Brain Research, D-60528
Frankfurt/Main, Germany. gruen@mpih-frankfurt.mpg.de
It has been
proposed that cortical neurons organize dynamically into functional
groups (cell assemblies) by the temporal structure of their joint
spiking activity. Here, we describe a novel method to detect
conspicuous patterns of coincident joint spike activity among
simultaneously recorded single neurons. The statistical significance of
these unitary events of coincident joint spike activity is evaluated by
the joint-surprise. The method is tested and calibrated on the basis of
simulated, stationary spike trains of independently firing neurons,
into which coincident joint spike events were inserted under controlled
conditions. The sensitivity and specificity of the method are
investigated for their dependence on physiological parameters (firing
rate, coincidence precision, coincidence pattern complexity) and
temporal resolution of the analysis. In the companion article in this
issue, we describe an extension of the method, designed to deal with
nonstationary firing rates.
PMID: 11747534 [PubMed - indexed for MEDLINE]
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