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Dynamic correlation of neuronal activity in rat cerebellar cortex modulated by behavior.
Heck D, Kummell F, Thach WT, Aertsena A.
University
of Freiburg, Institute of Biology III, Neurobiology Biophysics, 79104
Freiburg, Germany. heck@biologie.uni-freiburg.de
Sprague-Dawley
rats (2-4 months old) were trained to perform a reaching-grasping task
while their head was fixated and multielectrode recordings were
performed in the ipsilateral cerebellar hemisphere. Multiunit (MU)
activity was recorded with 2-3 electrodes in the Purkinje cell layer at
various depths (1.5-4.5 mm) from the pial surface while the animal
either performed the reaching-grasping task or was at rest. Recording
sites were visually aligned along the transverse or the sagittal axis
of Crus IIa. Excess correlations of MU spike activity were calculated
at 10-ms time resolution using the joint peristimulus time histogram
(JPSTH), to reveal the dynamics of cross-correlations corrected for
nonstationarities in spike rates. Peak correlation amplitudes and areas
were calculated separately for a time period preceding the movement and
for a succeeding period during which the movement occurred.
Correlations were compared across different paradigms: transversal
versus sagittal alignment of recordings sites and behavior versus rest.
No significant differences were found between transversally and
sagittally aligned recording sites. Significant differences in peak
correlation amplitude and/or peak area, however, were found both
between premovement and movement time, as well as between both these
time periods and periods while the animal was at rest.
PMID: 12582049 [PubMed - indexed for MEDLINE]
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