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Sequential stimulation of rat and guinea pig
cerebellar granular cells in vitro leads to increasing population
activity in parallel fibers.
Heck D.
Max-Planck-Institute for Biological Cybernetics, Tubingen, Germany. heck@biologie.uni-freiburg.d
Sequential
stimulation of the granular layer of the cerebellar cortex in vitro
using 11 linearly aligned stimulating electrodes leads to massive
population activity in the parallel fiber system and to spike activity
in Purkinje cells (Heck, D., Neurosci. Lett., 157 (1993) 95-98; Heck,
D., Naturwissenschaften, 82 (1995) 201-2030). The induced parallel
fiber activity, however, might have been a result of direct stimulation
of parallel fibers themselves and not of stimulation of granular cells
or their ascending axons. We report here that using sequential 'moving'
stimuli and varying the distance covered by the 'movement', parallel
fiber population spike amplitude increases with distance and saturates
for distances longer than 1.0 mm. This effect cannot be explained if
parallel fibers are directly stimulated, but requires stimulation of
the granular cells or their ascending axons. We conclude that the
population spike activity and Purkinje cell responses induced by
sequential stimulation of the granular layer of the cerebellar cortex
slices in this and earlier experiments consists of orthodromic parallel
fiber spikes.
PMID: 10213154 [PubMed - indexed for MEDLINE]
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