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Spike synchronization and rate modulation differentially involved in motor cortical function.
Riehle A, Grun S, Diesmann M, Aertsen A.
for Research in Cognitive Neuroscience, CNRS, 31 Chemin Joseph Aiguier,
13402 Marseille Cx 20, France. ariehle@Inf.cnrs-mrs.fr
It is now
commonly accepted that planning and execution of movements are based on
distributed processing by neuronal populations in motor cortical areas.
It is less clear, though, how these populations organize dynamically to
cope with the momentary computational demands. Simultaneously recorded
activities of neurons in the primary motor cortex of monkeys during
performance of a delayed-pointing task exhibited context-dependent,
rapid changes in the patterns of coincident action potentials. Accurate
spike synchronization occurred in relation to external events (stimuli,
movements) and was commonly accompanied by discharge rate modulations
but without precise time locking of the spikes to these external
events. Spike synchronization also occurred in relation to purely
internal events (stimulus expectancy), where firing rate modulations
were distinctly absent. These findings indicate that internally
generated synchronization of individual spike discharges may subserve
the cortical organization of cognitive motor processes.
PMID: 9395398 [PubMed - indexed for MEDLINE]