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Comment in:
Dynamics of ongoing activity: explanation of the large variability in evoked cortical responses.
Arieli A, Sterkin A, Grinvald A, Aertsen A.
Department of Neurobiology, Weizmann Institute of Science, Post Office Box 26, Rehovot 76100, Israel.
Evoked
activity in the mammalian cortex and the resulting behavioral responses
exhibit a large variability to repeated presentations of the same
stimulus. This study examined whether the variability can be attributed
to ongoing activity. Ongoing and evoked spatiotemporal activity
patterns in the cat visual cortex were measured with real-time optical
imaging; local field potentials and discharges of single neurons were
recorded simultaneously, by electrophysiological techniques. The evoked
activity appeared deterministic, and the variability resulted from the
dynamics of ongoing activity, presumably reflecting the instantaneous
state of cortical networks. In spite of the large variability, evoked
responses in single trials could be predicted by linear summation of
the deterministic response and the preceding ongoing activity. Ongoing
activity must play an important role in cortical function and cannot be
ignored in exploration of cognitive processes.
PMID: 8791593 [PubMed - indexed for MEDLINE]
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